Assess and harness novel approaches to the development of inhaled drug products for enhanced patient care.
05 Aug 2021
Friday, 06 August 2021
CASE STUDY: The impact of filling technology selection for dry powder formulations on device performance, process consistency and commercial scale-up
Consistent high efficiency aerosoliation performance is a critical quality attribute for all dry powder inhalers. There is a strong dependant relationship between the powder formulation, filling technology, device design and the device performance.
The desire to deliver a wider range of molecular types of drug has promoted a large increase in the use of engineered particle technologies e.g. spray drying for DPIs which require careful consideration of process conditions.
Highlight the impact of filling technology on device performance, process efficiency and manufacturing throughput. Could selection of the right filling technologies enable increased formulation and device design spaces.
Assess the potential issues due to filling technology with process scale-up to achieve continuity of performance as you move from bench, through clinic to commercial; minimising risk in the development process.
Affirm the importance of early stage filling trials on formulation selection and device design.