Mire Zloh is a Honorary Professor at the UCL School of Pharmacy.
Previously, Prof. Zloh has worked as Research Professor and Head of Pharmaceutical Chemistry at the University of Hertfordshire as well as a Senior Lecturer and Director of the Centre for Structural Chemistry at the UCL School of Pharmacy.
He was awarded an MSc in Physical Chemistry by University of Belgrade and earned a PhD in Chemistry at the University of London.
Prof. Mire Zloh has authored more 110 scientific publications and reviews. His research interests include drug design, structural chemistry and rational development of dendrimers as drug delivery systems. He is currently working on the method development for computer aided design of formulations.
Development of protein therapeutics formulation relies on the selection of excipients that stabilize protein and/or prevent aggregation.
Experimental strategies to optimize formulations use force degradation studies and involve screening many combinations of excipientsand buffers. However, these effective methods do not readily provide information on intermolecular interactions responsible for the protective effects of excipients.
In silico methods may be employed to evaluate interactions that may form between selected therapeutics during freeze drying pharmaceutical formulations. A combination of molecular docking methods has been successfully utilized to predict hotspots for protein excipient interfaces on a model protein, which were confirmed by molecular dynamics in presence of explicit solvent and buffer components.
Furthermore, simulated annealing simulations of freezing and drying processes provide insights into protective effects of formulations on a molecular level.
This combination of approaches could provide information about the interactions of excipients in formulations and guide the computer aided development of future formulations.View Details