Georg Frinke

Day 1: Wednesday, 13 February 2019

BLOCK: MANUFACTURING & PROCESS DEVELOPMENT.

CASE STUDY: MTM / BTM – a perpetual PAT Tool for Batch Based Lyo-Cycles.

• History, Current state and Latest development

With the beginning of industrial freeze drying in the late 40ies, a dynamic control procedure has been introduced. Based on steady scientific efforts, the performance of this procedure has been continuously improved. Though, this method has now become a robust detection procedure for the sublimation pressure at the ice front, there is still optimization potential remaining. The presentation will provide an historical overview and will discuss pro & cons of this measurement procedure. Finally an outlook will be provided.

Day 1: Wednesday, 12 February 2020

WORKSHOP: Use of refrigereants in Freeze Dryers – Discussion and impact of current solutions.

• Overview of refrigeration concepts
• Development of common refrigerants and specific environmental impact
• Comparison of energy efficiency of refrigeration principes
• Energy consumption of a Lyophilization cycle and resulting CO2 emission – with examples of existing installations and lyo-cycles
• Outlook of future refrigeration development
• Refitting the refrigeration system and Impact on cycle validation

Day 1: Thursday, 29 July 2021

CASE STUDY: Heat transfer at sublimation – a theoretical assessment of experimental results.

• Variable heat transfer on the shelf, reasons of edge effect
• Calculation of drying progress
• Experimental validation based on different PAT-Tools
• Assessment of current Qualification
• Risk mitigation for cycle transfer