Prof. Geoff Smith, De Montfort University - Qepler Summits And Conferences

Prof. Geoff Smith

Professor of Pharmaceutical Process Analytical Technology
De Montfort University
Leicester, United Kingdom
De Montfort University - Leicester, UK

Geoff Smith is Professor of Pharmaceutical Process Analytical Technology in the Leicester School of Pharmacy at De Montfort University (UK).

His research group focusses on pharmaceutical applications for impedance, dielectric and terahertz spectroscopies alongside optical techniques such as laser speckle and optical flow.

He is responsible for the development of through-vial impedance spectroscopy (TVIS) as a PAT tool for monitoring phase behaviour (ice formation and eutectics), ice interface temperatures, primary drying rates and end points. This development marks the first time that impedance spectroscopy has been used to characterize materials within conventional glass freeze-drying vials, without having to insert the electrodes into the product (i.e. the solution under-going freeze-drying). This feature of the technology sets it apart from other in-process impedance measurement systems, in which a bulky electrode assembly is inserted into the solution being freeze-dried, to provide a product-non-invasive technology.

Related Sessions:

Pharmaceutical Lyophilization
Summit 2019

Discuss best practices in tech & regulatory updates, process, formulation, testing, monitoring and new products development.
  • 13 Feb 2019
  • Prague, CZ
  • Pharma
Day 1: Wednesday, 13 February 2019
CASE STUDY: Impedance Spectroscopy: Recent Developments as a Process Analytical Technology for Pharmaceutical Freeze-Drying.
  • Impedance spectroscopy for beginners
  • Through Vial Impedance Spectroscopy (TVIS)
  • Applications: (i) ice nucleation; (ii) 1° drying rate; (iii) product temperatures; (iv) Kv and Rp determination
  • Accelerated design space assessment
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2nd Annual Pharmaceutical
Lyophilization Summit 2020

Discuss best practices in tech & regulatory updates, process, formulation, testing, monitoring, new products development.
  • 12 Feb 2020
  • Berlin, DE
  • Pharma
Day 2: Thursday, 13 February 2020
CASE STUDY: Z-FDM : A new instrument combining impedance spectroscopy with a freeze drying microscope.
  • Theory: broad band dielectric relaxation spectroscopy of frozen solutions
  • Z-FDM: A description of the new measurement system
  • Applications in freezing (nucleation temperature, ice growth rates, solidification end point)
  • Applications in primary drying (drying rate, product collapse)
  • Future applications for high throughput screening (concurrent product and process design)
View Details