Andrea Guytingco

Day 2: Thursday, 23 February 2023

CASE STUDY: Exposure Assessment Challenges for New Modality Potent Compounds in R&D

As the shift in the pharmaceutical R&D environment goes from small molecule, solid, powder handling transitions to large molecule, liquid handling, how does Industrial Hygiene and the greater EHS team adapt to new methods of risk assessment and control? This presentations addresses:

• The partnership of Industrial Hygiene and Biosafety practices to mitigate employee exposure to pharmaceutical ingredients that have both biological and chemical components or require additional employee protection.
• Understanding that traditional Industrial Hygiene risk assessments can be difficult when there is limited knowledge or data on the API being handed. How do we make our best educated recommendation on controls that’s not overly conservative?
• Designing spaces for adaptability and flexibility.
• Case studies highlighting the challenges of controlling for new modality potent compounds in an R&D setting.